摘要 |
PURPOSE: To obtain a composition capable of selectively reinforcing opiate activities induced byμreceptor and simultaneously reducing opiate tolerance and dependence by including opiate painkiller andδreceptor agonist. CONSTITUTION: This composition includes an opiate painkiller such as morphine, heroin, hydromorphone, oxymorphone, codeine and levorphanol, and endogenic or exogenous, and directly or indirectly actingδagonist simultaneously administered. [D-Pen<2> , D-Pen<5> ]enkephalin, [D-Ser<2> , Leu<5> , Thr<6> ]enkephalin, leucine-enkephalin, thiorphan, (R)-3-(N-hydroxy-carboxamido-2-benzylpropanoyl)-L- phenylalanine, etc., are used as theδreceptor-agonist.
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