发明名称 |
Specificity grafting of a murine antibody onto a human framework |
摘要 |
The current invention provides new human variable chain framework regions and humanized antibodies comprising the framework regions. The invention also provides a new method of identifying framework acceptor regions in framework sequences for backmutation to graft a donor sequence to the human framework.
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申请公布号 |
US2006194276(A1) |
申请公布日期 |
2006.08.31 |
申请号 |
US20040515149 |
申请日期 |
2004.11.18 |
申请人 |
UNIVERSITY OF READING |
发明人 |
KRAUSS JURGEN;ARNDT MICHAELA;MARTIN ANDREW S.;RYBAK SUSANNA |
分类号 |
C12P21/06;C07H21/04;C07K14/52;C07K16/28;C07K16/44;C12N5/06;C12N9/00;C12N15/13;C12P21/08 |
主分类号 |
C12P21/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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