EMULSION FORMULATIONS OF APREPITANT

摘要

Disclosed herein are novel pharmaceutical formulations of aprepitant suitable for parenteral administration including intravenous administration. Also included are formulations including both aprepitant and dexamethasone sodium phosphate. The pharmaceutical formulations are stable oil-in-water emulsions for non-oral treatment of emesis and are particularly useful for treatment of subjects undergoing highly emetogenic cancer chemotherapy.

主权项

1. An injectable pharmaceutical emulsion comprising:
0.4 wt/wt % to 1.0 wt/wt % aprepitant; 13 wt/wt % to 15 wt/wt % egg yolk lecithin; 9 wt/wt % to 10 wt/wt % soybean oil; and a pH modifier, wherein the pH modifier is sodium oleate; wherein the pH of the emulsion ranges from 7.5 to 9.0.