| 发明名称 |
ZAP70 PROTEIN EXPRESSION AS A MARKER FOR CHRONIC LYMPHOCYTICLEUKEMIA/SMALL LYMPHOCYTIC LYMPHOMA(CLL/SLL) |
| 摘要 |
It has been surprisingly found that ZAP-70 expression, both at the protein and mRNA levels, is indicative of clinical subgroups of CLL/SLL patients. In particular, high ZAP-70 expression is indicative of Ig-unmutated CLL/SLL. Methods are provided for discriminating between clinical subgroups of CLL/SL L, by determining whether subjects overexpress ZAP-70 mRNA or protein.
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| 申请公布号 |
CA2413475(A1) |
申请公布日期 |
2003.10.25 |
| 申请号 |
CA20022413475 |
申请日期 |
2002.12.03 |
| 申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SEC RET |
发明人 |
WIESTNER, ADRIAN;STAUDT, LOUIS M.;BARRY, TODD S.;ROSENWALD, ANDREAS;WILSON, WYNDHAM |
| 分类号 |
C12N15/11;C12Q1/68;G01N33/543;G01N33/574;(IPC1-7):C12N15/11 |
主分类号 |
C12N15/11 |
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