A PROCESS FOR THE PREPARATION OF A COMBINATION OF FAMOTIDINEPOLYMORPHIS A AND B

摘要

A process for the preparation of a combination of Famotidine [Chemical Name (N- Sulfamyl - 3-(2-guanidinothiazole-4-yl-methylthio) proionamidine] Polymorphs A and B comprising the following steps:- (a) dissolving Famotidine crude in solvent such as methanol under heating an d stirring to form a solution; (b) adding activated carbon to the solution of step (a) at 45.degree.C for 3 0 minutes; (c) filtering the solution of step (a) to obtain a clear colourless solution ; (d) concentrating the solution under vacuum at a temperature of 4.5.degree.C to 58.degree.C under vacuum to get a crystalline slurry; (e) filtering out the crystals of Famotidine Polymorphs A and B combination; (f) drying the said crystals of Famotidine Polymorphs A and B combination in an oven.