Process for Producing Lercanidipine

摘要

A process for preparing 1,4-dihydro-2,6-dimethyl-4- (3-nitrophenyl) -3,5-pyridinedicarboxylic acid 2- [(3,3-diphenyl-propyl) methylamino]-1,1-dimethylethyl ester (Lercanidipine) I, which comprises reacting 1,4-dihydro-2,6-dimethyl-4- (3-nitrophenyl) -3,5-pyridinedicarboxylic acid 1,1-dimethylethyl-2-methylamino ethyl methyl ester IX or a salt thereof with a compound of the general formula L-O-CH 2 -CH 2 -CHPh 2 where L-O is a leaving group.