| 发明名称 |
CARRIER FOR USE IN DELIVERING DRUG, CONJUGATE, COMPOSITION COMPRISING SAME, AND METHOD FOR ADMINISTRATING SAME |
| 摘要 |
The present invention provides a vesicle, a conjugate, a composition comprising the vesicle or the conjugate, for use in delivering a drug to the brain, and a method for administering the same. The composition of the present invention is a composition for administration to a subject according to a dosing regimen, comprising a carrier for drug delivery, wherein the dosing regimen comprises administering the composition to a subject who has been fasted or caused to have hypoglycemia and inducing an increase in blood glucose level in the subject, and the carrier is modified at the outer surface thereof with a GLUT1 ligand. |
| 申请公布号 |
US2016287714(A1) |
申请公布日期 |
2016.10.06 |
| 申请号 |
US201415038374 |
申请日期 |
2014.11.21 |
| 申请人 |
THE UNIVERSITY OF TOKYO ;NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY |
发明人 |
KATAOKA Kazunori;ANRAKU Yasutaka;NISHIYAMA Nobuhiro;MIYATA Kanjiro;ISHII Takehiko;MATSUMOTO Yu;FUKUSATO Yu;MIZOGUCHI Akihiro;YOKOTA Takanori;KUWAHARA Hiroya;NISHINA Kazutaka;MIZUSAWA Hidehiro |
| 分类号 |
A61K47/48;A61K31/7088;A61K39/44;A61K9/00 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A composition for administration to a subject according to a dosing regimen, the composition comprising a carrier for drug delivery, wherein:
the dosing regimen comprises administering the composition to a subject who has been fasted or caused to have hypoglycemia and inducing an increase in blood glucose level in the subject; and the carrier is modified at an outer surface thereof with a GLUT1 ligand. |
| 地址 |
Bunkyo-ku, Tokyo JP |
