| 摘要 |
<p>Butadiene compounds represented by general formula (I) (wherein R1 represents hydrogen, lower alkyl, carboxy-lower alkyl, amino-lower alkyl, mono- or di-lower alkylamino-lower alkyl or aralkyl, n R2 groups each represent halogen, lower alkyl, lower alkoxy or hydroxy, R3 represents hydrogen or lower alkyl, Het represents pyridyl, N-lower alkyl-pyridinium, quinolyl, 4-oxo-3H-quinazolyl, and n represents 0 or an integer of 1 to 4, provided that when n represents an integer of 2 to 4, n R2 groups may be the same or different from each other) and their salts are disclosed. The butadiene compounds and their salts possess 5-lipoxygenase inhibiting activity, lipid peroxidation preventing action, leucotriene D4-antagonistic action, activity of inhibiting the release of histamine and SRS-A, etc. and are useful as agents for treating various diseases such as bronchial asthma, allergic diseases (e.g., allergic rhinitis), immunological diseases (e.g., auto-immunodeficiency, infectious diseases, etc.), inflammatory diseases (e.g., articular rheumatism, ankylosing spondylitis, etc.), psoriasis, cerebrovascular disease, ischemic heart disease, thrombosis, etc.</p> |
