CYCLOPENTAN(EN)OIC ACID, 2-ALKENYL DERIVATIVES AS THERAPEUTIC AGENTS IN THE TREATMENT OF OCULAR HYPERTENSION

摘要

The invention relates to the use of omega chain modified prostaglandins as ocular hypotensive. The derivatives used in accordance with the invention are encompassed by structure formula (I): wherein the hatched segments represent .alpha. bonds; the wavy segments represent an .alpha. or .beta. bond; dashed lines represent a double bond or a single bond; X is selected from the group consisting of -OR and N(R2); Y is = O or represents 2 hydrogen radicals, provided that Y represents 2 hydrogen radicals when X is OH; R is hydrogen or a lower radical having up to six carbon atoms; R is = O or hydroxy; m is = 0, 2, 4 or 6, provided that m is not 4 when the wavy segment represents a .beta. bond; n is 0, 2, 4 or 6, x and y are 0 or 1, provided that x is 1 when y is 0 and y is 1 when x is 0; or 9, 11 and/or 15 ester derivatives of said compounds of formula (I), e.g. a C1 and C6 alkyl ester derivative; or a pharmaceutical acceptable salt thereof.