Topical steroidal formulations

摘要

The present invention relates to formulations of poorly water soluble pharmaceutical agents of Formula I and II. The present invention also relates to compositions containing compounds of Formula I or II, and glucocorticoids, and methods for reducing side effects from glucocorticoid treatment by co-administration of compounds of Formula I and II. The compositions herein are useful for the treatment of diabetes and obesity related diseases including metabolic syndrome.;

主权项

1. A pharmaceutical composition comprising nanosized particles of a compound of Formula I: wherein:
R1, R2 and R7 are hydrogen;R3, R4, R5 and R6, are each individually hydrogen or lower alkyl;X is halogen, hydrogen or lower alkyl;Z is hydrogen or lower alkyl; andn is 1 or 2;wherein at least one of X and Z is not hydrogen; and suspended in a mixture comprising a lower alkyl alcohol, a surfactant, and optionally, a long chain alcohol.