| 发明名称 |
Materials and methods relating to a novel retrovirus |
| 摘要 |
The present invention relates to a novel retrovirus associated with autoimmune disease. The present invention provided nucleotide and amino acid sequence relating to GAG, PRO and POL proteins of the retrovirus as well as diagnostic techniques and antibodies for use in diagnosis. The retrovirus (HRV-5) according to the present invention has been detected in inflamed joints (RA, osteoarthritis (OA), reactive arthritis and psoriatic arthritis) but not normal synovium. Further, HRV-5 proviral DNA has been detected in blood from patients with RA and systemic lupus erythematosus (SLE). |
| 申请公布号 |
AU3157799(A) |
申请公布日期 |
1999.10.18 |
| 申请号 |
AU19990031577 |
申请日期 |
1999.03.26 |
| 申请人 |
INSTITUTE OF CANCER RESEARCH;THE MATHILDA, TERENCE KENNEDY INSTITUTE OF RHEUMATOLOGY |
发明人 |
DAVID JOHN GRIFFITHS;ROBERT ANTHONY WEISS;PATRICK JOHN WOODGATE VENABLES;MARK THOMAS BOYD |
| 分类号 |
G01N33/569;A61K31/7088;A61K35/76;A61K38/00;A61K39/00;A61K39/395;A61K45/00;A61K48/00;A61P19/02;A61P29/00;A61P37/06;C07K14/15;C07K16/10;C12N7/00;C12N15/09;C12P21/08;C12Q1/68;C12Q1/70 |
主分类号 |
G01N33/569 |
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