| 发明名称 |
High affinity tgfbeta nucleic acid ligands and inhibitors |
| 摘要 |
Methods are described for the identification and preparation of high-affinity nucleic acid ligands to TGF beta . Included in the invention are specific RNA ligands to TGF beta 1 identified by the SELEX method. Also included are RNA ligands that inhibit the interaction of TGF beta 1 with its receptor. |
| 申请公布号 |
AU3010699(A) |
申请公布日期 |
1999.10.18 |
| 申请号 |
AU19990030106 |
申请日期 |
1999.03.18 |
| 申请人 |
NEXSTAR PHARMACEUTICALS, INC. |
发明人 |
LARRY GOLD;NIKOS PAGRATIS |
| 分类号 |
A61K38/00;C07B61/00;C07H19/06;C07H19/10;C07H21/00;C07K14/00;C07K14/49;C07K14/495;C07K14/50;C12N9/12;C12N15/10;C12N15/113;C12N15/115;C12Q1/37;C12Q1/68;C12Q1/70;F02B75/02;G01N33/531;G01N33/532;G01N33/535;G01N33/569;G01N33/68;G01N33/76 |
主分类号 |
A61K38/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
