发明名称 |
NOVEL GLUTAMIC ACID DECARBOXYLASE (GAD) PROTEINS AND METHODS OF USE |
摘要 |
The invention relates to novel Glutamic Acid Decarboxylases (GAD). More specifically, novel DNA and protein sequences relating to GAD. Additionally, the invention discloses a novel composition and related methods for treating neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, epilepsy, and the like, using viral and non-viral delivery systems that deliver therapeutic agents to specific regions of the brain. More specifically, using an adeno-associated viral vector to deliver a nucleotide sequence encoding a novel glutamic acid decarboxylase (GAD) to specific regions of the brain that are over stimulated or disinhibited in various diseases, including neurodegenerative diseases. |
申请公布号 |
WO2008016629(A3) |
申请公布日期 |
2008.04.24 |
申请号 |
WO2007US17157 |
申请日期 |
2007.08.01 |
申请人 |
NEUROLOGIX, INC.;FITZSIMONS, HELEN;BLAND, ROSS |
发明人 |
FITZSIMONS, HELEN;BLAND, ROSS |
分类号 |
C12N9/88;A61K48/00;C07K16/40 |
主分类号 |
C12N9/88 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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