Prion epitopes and methods of use thereof

摘要

Prion peptides comprising prion epitopes and fusions thereof, that display enhanced immunogenicity are described. Also described are methods of treating and diagnosing prion disease.

主权项

1. An isolated immunogenic peptide comprising three or more repeats of an epitope that comprises the amino acid sequence VYYRP (SEQ ID NO: 10) in a linear or an inverted orientation, wherein one or more of the three repeats is in an inverted orientation.