| 摘要 |
Fumarate compounds, pharmaceutical compositions comprising the fumarate compounds, and methods of using fumarate compounds and pharmaceutical compositions for treating neurodegenerative, inflammatory, and autoimmune disorders including multiple sclerosis, psoriasis, irritable bowel disorder, ulcerative colitis, arthritis, chronic obstructive pulmonary disease, asthma, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are disclosed. |
| 主权项 |
1. A compound according to Formula (I): or a pharmaceutically acceptable salt thereof, wherein: R1 is selected from the group consisting of hydrogen, C1-6 alkyl, substituted C1-6 alkyl, C1-6 heteroalkyl, substituted C1-6 heteroalkyl, C3-12 cycloalkyl, substituted C3-12 cycloalkyl, C3-12 heterocycloalkyl, substituted C3-12 heterocycloalkyl, C5-10 aryl, substituted C5-10 aryl, C5-10 heteroaryl, and substituted C5-10 heteroaryl; R2 and R3 together with the carbon to which they are bonded form a (2,4-dioxo-1H-pyrimidin-5-yl) ring; and X1 and X2 are independently selected from the group consisting of a bond and C1-6 alkane-diyl; wherein each substituent group is independently selected from the group consisting of halogen, —OH, —CN, —CF3, ═O, —NO2, benzyl, —C(O)N(R21)2, —R21, —OR21, —C(O)R21, —C(O)OR21, —N(R21)2, —NR21C(O)R21, and —O(O)R21, wherein each R21 is independently selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 heteroalkyl, C3-12 cycloalkyl, C5-10 aryl, C5-10 heteroaryl, and amino acid side chain. |
