| 摘要 |
PCT No. PCT/US93/06827 Sec. 371 Date Apr. 25, 1995 Sec. 102(e) Date Apr. 25, 1995 PCT Filed Jul. 23, 1993 PCT Pub. No. WO94/10166 PCT Pub. Date May 11, 1994The present invention is directed to compounds of formula (I), and the pharmaceutically acceptable acid addition salts thereof, wherein R is selected from the group consisting of F,-CF3, -OCH3, -O(C1)alkyl substituted with 1 to 3 fluoro atoms. -O(C2) substituted with 1 to 5 fluoro atoms, and -O(C3)alkyl substituted with 1 to 7 fluoro atoms. The compounds of formula (I) are useful in the treatment of stroke, traumatic brain injury and central nervous system degenerative diseases.
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