New N-phenyl-benzoxazole or -benzthiazole derivatives, useful for treating e.g. diabetes and cancers, are modulators of the peroxisome-activated receptors

摘要

N-phenyl-benzoxazole or -benzothiazole derivatives (I) and their enantiomers, diastereoisomers and addition salts with acids or bases are new. N-phenyl-benzoxazole or -benzothiazole derivatives of formula (I) and their enantiomers, diastereoisomers and addition salts with acids or bases are new. A = phenyl or pyridyl, both optionally substituted by 1-3 of alkyl, alkoxy, hydroxy, COOR, CHO, amino (optionally substituted by 1 or 2 alkyl), trihaloalkyl or halo; R = hydrogen or alkyl; X and Y = oxygen or sulfur; R1 and R2 = COOR5; R5 = hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkylalkyl; R3 and R4 = hydrogen; R3R4 = fused mono- or poly-cyclic group that has 5-10 ring members, optionally contains one or more unsaturations and/or 1-3 heteroatoms (oxygen, sulfur or nitrogen) and/or is optionally substituted by 1-3 alkyl, alkoxy, hydroxy, COOR, CHO, amino (optionally substituted by 1 or 2 alkyl), trihaloalkyl, spiro-alkylenedioxy, or halo; and provided that: (1) all alkyl have 1-6C and alkenyl or alkynyl have 2-6C; and (2) A cannot be a group of formula (i). R = H or alkyl. An Independent claim is also included for the preparation of (I).