发明名称 |
PROCESS FOR PRODUCTION OF 4(3H)-QUINAZOLINONE DERIVATIVE |
摘要 |
The present invention provides a process for producing a 4(3H)-quinazolinone derivative, which is useful as a medicinal substance, with better efficiency in an industrial scale. The process comprises the steps of reacting 4-hydroxy-N-tert-butoxycarbonylpiperidine with 4-fluoro-1-nitrobenzene in the presence of sodium hydride, reacting the resulting product with cyclobutanone, reducing the resulting product to give 4-(1-cyclobutyl-4-piperidinyl)oxyaniline, and reacting this compound with 2-methyl-5-trifluoromethyl-4H-3,1-benzoxazin-4-one to give 3-{4-[{1-cyclobutyl-4-piperidinyl)oxy]phenyl}-2-methyl-5-trifluoromethyl-4(3H)-quinazolinone.
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申请公布号 |
EP1900733(A1) |
申请公布日期 |
2008.03.19 |
申请号 |
EP20060747292 |
申请日期 |
2006.06.07 |
申请人 |
BANYU PHARMACEUTICAL CO., LTD. |
发明人 |
NAGASE, TSUYOSHI;SATO, NAGAAKI;KII, SATOSHI;SATO, KIMIHIKO;TSURITANI, TAKAYUKI;SAWADA, NAOTAKA |
分类号 |
C07D401/12 |
主分类号 |
C07D401/12 |
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