| 摘要 |
Optically active cyanohydrins are prepared by addition of hydrogen cyanide to aldehydes in the presence of catalysts which comprise the dipeptide derivative represented by the formula (* CHEMICAL STRUCTURE *) (I) wherein R1 represents an isopropyl group, an isobutyl group, a sec-butyl group, a tert-butyl group, a methyl group, a benzyl group or a phenyl group, R2 represents a benzyl group, an indol-3-ylmethyl group, an isopropyl group, an isobutyl group or a phenyl group, R3 represents a lower alkoxy group, a hydroxy group or a mono- or di-lower alkylamino group, R4 represents a hydrogen atom, or R2 and R4 are bonded together at their terminals to form a CH2CH2CH2 group, R5, R6, R7 and R8 are the same or different, and each represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group or R5 and R6, R6 and R7, or R7 and R8 are bonded together at their terminals to form CH=CH-CH=CH or OCH2O, and * denotes an absolute configuration of S or R, and a titanium (IV) alkoxide.
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