VACCINES FOR PREVENTING MENINGOCOCCAL INFECTIONS

摘要

The present invention stems from the finding that the interaction between the β2 adrenoceptor (β2AP) and type IV pilus-associated proteins initiates a process leading to the opening of the blood-brain barrier. The invention therefore pertains to a vaccine for preventing the spreading of meningococci into the meningeal space, wherein said vaccine allows the production of antibodies inhibiting the interaction between the type IV pilus-associated proteins and the β2AP.

主权项

1. A method for preventing the spreading of meningococci into the meningeal space in a subject comprising the step of administering to a subject in need thereof an effective amount of a meningococcal PilE or PilV protein, or an immunogenic fragment of at least 10 consecutive amino acids thereof.