SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS

摘要

The use of a compound of formula (I) or a salt, ester or amide thereof; where X is O, or S, S(O) or S(O)2, or NR<6> where R<6> is hydrogen or C1-6alkyl; R<5> is an optionally substituted 5-membered heteroaromatic ring, R<1>, R<2>, R<3>, R<4> are independently selected from various specified moieties, in the preparation of a medicament for use in the inhibition of aurora 2 kinase. Certain compounds are novel and these, together with pharmaceutical compositions containing them are also described and claimed.