| 发明名称 | Application of mRNA for use as a therapeutic against tumor diseases | ||
| 摘要 | The present invention relates to a pharmaceutical composition comprising at least one mRNA comprising at least one coding region for at least one antigen from a tumor, in combination with an aqueous solvent and preferably a cytokine, e.g. GM-CSF, and a process for the preparation of the pharmaceutical composition. The pharmaceutical composition according to the invention is used in particular for therapy and/or prophylaxis against cancer. | ||
| 申请公布号 | US9433669(B2) | 申请公布日期 | 2016.09.06 |
| 申请号 | US201514965485 | 申请日期 | 2015.12.10 |
| 申请人 | CureVac AG | 发明人 | Hoerr Ingmar;Von Der Mülbe Florian;Pascolo Steve |
| 分类号 | A61K39/00;A61K38/19;A61K9/00;A61K48/00 | 主分类号 | A61K39/00 |
| 代理机构 | Parker Highlander PLLC | 代理人 | Parker Highlander PLLC |
| 主权项 | 1. A method of stimulating an antitumor immune response in a subject comprising administering an effective amount of a cell-free composition comprising mRNA encoding an PSMA antigen to a subject in need thereof, thereby stimulating a T-cell mediated cytotoxic anticancer immune response in the subject. | ||
| 地址 | Tübingen DE | ||