VEGF antagonist compositions and uses thereof

摘要

The invention provides compositions and methods for treating a disease or disorder associated with vascular endothelial growth factor (VEGF). Specifically, the invention relates to an oligomerized VEGF binding domain to provide VEGF antagonism, and thereby treat diseases associated thereof.

主权项

1. A vascular endothelial growth factor (VEGF) antagonist oligomer comprising: a plurality of monomers operably linked to each other, wherein each monomer comprises the second VEGF binding domain (D2) of FMS-like tyrosine kinase-1 (FLT-1), and wherein the plurality of monomers are linked to each other through a non-protein polymer.