| 发明名称 | Antibody recognizing folate receptors α and β | ||
| 摘要 | The object of the present invention is to provide an antibody capable of immunologically and specifically binding to a folate receptor α and a folate receptor β. Specifically, the present invention relates to an antibody or a fragment thereof, in which the amino acid sequences of CDRH1, CDRH2, and CDRH3 of a heavy chain variable region (VH) are SEQ ID NOs: 2, 4, and 6, respectively, and the amino acid sequences of CDRL1, CDRL2, and CDRL3 of a light chain variable region (VL) are SEQ ID NOs: 10, 12, and 14, respectively. | ||
| 申请公布号 | US9522196(B2) | 申请公布日期 | 2016.12.20 |
| 申请号 | US201314654951 | 申请日期 | 2013.12.19 |
| 申请人 | KAGOSHIMA UNIVERSITY | 发明人 | Matsuyama Takami;Nagai Taku;Hasui Kazuhisa;Takao Sonshin |
| 分类号 | A61K39/395;A61K47/48;C07K16/46;C07K16/30;C07K16/28;A61K51/10;A61K38/16;A61K39/00 | 主分类号 | A61K39/395 |
| 代理机构 | Lucas & Mercanti, LLP | 代理人 | Lucas & Mercanti, LLP |
| 主权项 | 1. An antibody, or a fragment thereof, capable of immunologically and specifically binding to a folate receptor α and a folate receptor β, in which the amino acid sequences of CDRH1, CDRH2, and CDRH3 of a heavy chain variable region (VH) are the amino acid sequences of SEQ ID NOs: 2, 4, and 6, respectively, and the amino acid sequences of CDRL1, CDRL2, and CDRL3 of a light chain variable region (VL) are the amino acid sequences of SEQ ID NOs: 10, 12, and 14, respectively. | ||
| 地址 | Kagoshima JP | ||