| 摘要 |
<p>An aerosol pharmaceutical formulation comprises a proteinic pharmaceutical agent, water, a phenol and a propellant. The phenol is phenol and/or methyl phenol in a concentration of from 1 to 10 wt./wt.% of the total formulation. The propellant is a C1-C2 dialkyl ether, butanes, fluorocarbon propellant, hydrogen-containing fluorocarbon propellant, chlorofluorocarbon propellant, or hydrogen-containing chlorofluorocarbon propellant, or mixtures thereof. Optionally, excipients selected from salts, antioxidants, coloring agents, flavouring agents, protease inhibitors, stabilizers, glycerin, polyglycerin, lysine, polylysine and mixtures thereof, may be present. Preferably, the formulation is administered buccally, using a metered dose dispenser.</p> |
