COMPOUNDS FOR DISEASES AND DISORDERS

摘要

The invention provides novel compounds useful for the treatment of disorders associated with a defect in vesicular transport (e.g., axonal transport). The compounds have a substituents chosen from -L-C(-O)OH, -L-CH-CHC(-O)OH, -L-C(-O)NH2, -L-C(-O)NH(C1-3 alkyl), -L-C(-O)N(C1-3 alkyl)2, -L-S(-O)2(C1-3alkyl), -L-S(-O)2NH2, -L-S(-O)2N(C1-3 alkyl)2, -L-S(-O)2NH(C1-3 alkyl), -L-C(-O)NHOH, -L-C(-O)CH2NH2, -L-C(-O)CH2OH, -L-C(-O)CH2SH, -L-C(-O)NHCN, -L-NHC(-O)ORo, -L-C(-O)NHRo, -L-NH(C-O)NHRo, -L-C(-O)N(Ro)2, -L-NH(C-O)N(Ro)2, -L-sulfo, -L-(2,6 difluorophenol), -L-phosphono, and -L-tetrazolyl, where L is a linker.