| 发明名称 |
SUBSTITUTED 3-PHENYLPROPYLAMINE DERIVATIVES FOR THE TREATMENT OF OPHTHALMIC DISEASES AND DISORDERS |
| 摘要 |
The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are substituted 3-phenylpropylamine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease. |
| 申请公布号 |
US2016229831(A1) |
申请公布日期 |
2016.08.11 |
| 申请号 |
US201514849859 |
申请日期 |
2015.09.10 |
| 申请人 |
Acucela Inc. |
发明人 |
Kuksa Vladimir A.;Orme Mark W.;Hong Feng;Kubota Ryo |
| 分类号 |
C07D335/02;C07D213/38;C07D211/26;C07D307/81;C07D307/14;C07D211/60;C07D233/96;C07D311/04;C07D207/09;C07D211/76;C07D333/12;C07D207/26;C07D279/02;C07D211/96;C07D209/08;C07D233/64;C07D309/06 |
主分类号 |
C07D335/02 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A compound of Formula (C), or a pharmaceutically acceptable salt thereof: wherein, A is selected from —O— or —CH2—; Y is RA is OH, RB is H; or optionally, RA and RB together form an oxo; R1 and R2 are each independently selected from hydrogen, C1-C4 alkyl, —C(═O)R3; and R3 is selected from alkyl, alkoxy, or —OCH2OC(O)R4, wherein R4 is an alkyl or alkoxy. |
| 地址 |
Seattle WA US |
