| 发明名称 | Antibodies containing therapeutic TPO/EPO mimetic peptides | ||
| 摘要 | The present disclosure features therapeutic antibodies (e.g., TPO mimetic antibodies) and therapeutically-active fragments thereof as well as methods for preparing and using the antibodies and fragments. For example, the therapeutic antibodies and their fragments are useful in a variety of diagnostic and/or therapeutic applications such as methods for increasing platelet levels in a subject. | ||
| 申请公布号 | US9493551(B2) | 申请公布日期 | 2016.11.15 |
| 申请号 | US201013202932 | 申请日期 | 2010.02.18 |
| 申请人 | Alexion Pharmaceuticals, Inc. | 发明人 | Springhorn Jeremy P.;Gies David |
| 分类号 | C07K16/18;C07K7/08;C07K14/52;A61K38/00;G01N33/86;A61K39/00 | 主分类号 | C07K16/18 |
| 代理机构 | Nelson Mullins Riley & Scarborough LLP | 代理人 | Nelson Mullins Riley & Scarborough LLP ;Remillard, Esq. Jane E.;Frank Christopher L. |
| 主权项 | 1. A polypeptide which comprises: (i) a light chain polypeptide comprising the amino acid sequence depicted in SEQ ID NO: 10; (ii) a heavy chain polypeptide comprising the amino acid sequence depicted in SEQ ID NO: 12; or (iii) a light chain polypeptide comprising the amino acid sequence depicted in SEQ ID NO: 10 and a heavy chain polypeptide comprising the amino acid sequence depicted in SEQ ID NO: 12. | ||
| 地址 | New Haven CT US | ||