发明名称 |
Osteoclast secreted chemokine and uses thereof |
摘要 |
The present invention demonstrates the biological function of a newly identified osteoclast-secreted protein. This protein, mim-1, has sequence homology with but is distinct from a previously identified neutrophil chemokine protein. Mim-1 may be a key signaling protein secreted by osteoclasts that regulates recruitment and/or differentiation of osteoblast and osteoclast precursor cells. This protein may also serve to maintain osteoclasts in a relatively inactive state prior to secretion. This mechanism is essential for regulating the mass and structural integrity of bone. This protein or an analog and/or antagonists of this protein will have potential therapeutic potential in the treatment of a variety of pathological bone diseases including osteoporosis and metastatic bone diseases. |
申请公布号 |
AU6992201(A) |
申请公布日期 |
2002.01.02 |
申请号 |
AU20010069922 |
申请日期 |
2001.06.19 |
申请人 |
THE UAB RESEARCH FOUNDATION |
发明人 |
JOHN P. WILLIAMS;JAY M. MCDONALD;MARGARET A. MCKENNA |
分类号 |
A61K38/17;A61K38/19 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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