This invention provides compounds, compositions and methods for modulating the expression of human GST-π using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. A nucleic acid molecule can have a) a polynucleotide sense strand and a polynucleotide antisense strand; b) each strand of the molecule being from 15 to 30 nucleotides in length; c) a contiguous region of from 15 to 30 nucleotides of the antisense strand being complementary to a sequence of an mRNA encoding GST-π; and d) at least a portion of the sense strand can be complementary to at least a portion of the antisense strand, and the molecule has a duplex region of from 15 to 30 nucleotides in length
申请公布号
WO2016106406(A2)
申请公布日期
2016.06.30
申请号
WO2015US67561
申请日期
2015.12.28
申请人
NITTO DENKO CORPORATION;YING, WENBIN
发明人
YING, WENBIN;MINOMI, KENJIROU;HARBORTH, JENS;TAKAHASHI, HIROKAZU;TERADA, ERIKA;ZHANG, JUN;AHMADIAN, MOHAMMAD