发明名称 |
Wnt signaling inhibitor comprising insulin-like growth factor-binding protein |
摘要 |
Provided is a novel soluble factor that modulates morphogenesis and cell proliferation, such as cardiac development and/or cardiomyocyte differentiation. Specifically provided are: an inhibitor of Wnt signalling, comprising an insulin-like growth-factor-binding protein (IGFBP), the protein being binding to a Wnt receptor, and/or a polynucleotide encoding the protein; a medicament for prevention and/or treatment of a disease due to enhanced Wnt signalling, comprising the inhibitor of Wnt signalling, and a medicament for induction of cardiomyocyte differentiation; and a method for prevention and/or treatment of a disease due to enhanced Wnt signalling and a method of inducing cardiomyocyte differentiation, the methods each comprising using the inhibitor of Wnt signalling, and a cardiomyocyte, which is obtained by the method of inducing cardiomyocyte differentiation, and a use thereof. |
申请公布号 |
US9427457(B2) |
申请公布日期 |
2016.08.30 |
申请号 |
US201514633155 |
申请日期 |
2015.02.27 |
申请人 |
National University Corporation Chiba University |
发明人 |
Komuro Issei;Shiojima Ichiro;Zhu Weidong |
分类号 |
A61K38/17;A61K31/7088;A61K48/00;C07K14/47;C12N15/113;C12N5/09;A61K38/00 |
主分类号 |
A61K38/17 |
代理机构 |
Kilyk & Bowersox, P.L.L.C. |
代理人 |
Kilyk & Bowersox, P.L.L.C. |
主权项 |
1. A method of inhibiting Wnt signalling, comprising contacting an insulin-like growth-factor-binding protein (IGFBP) with a Wnt receptor in vitro, wherein the insulin-like growth-factor-binding protein (IGFBP) is a protein represented by an amino acid sequence set forth in SEQ ID NO: 2 of Sequence Listing. |
地址 |
Chiba JP |