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1. A compound of formula Iwherein
A is a ring selected from the group consisting of phenyl and 6-membered hetaryl containing 1 or 2 nitrogen atoms as ring members, where ring A carries one substituent R6 and optionally one substituent R7; B is a ring selected from the group consisting of phenyl, pyridyl and quinolinyl, where ring B may carry 1, 2 or 3 substituents R8; X1 is NH, CH2 or O; X2 is N or CH; X3, X4, X5 and X6, independently of each other, are selected from the group consisting of —CH2—, —O—, —S(O)c—, —NH—, —C(O)—, —CH2CH2—, —CH2O—, —OCH2—, —S(O)cCH2—,
—CH2S(O)c—, CH2NH—, —NHCH2—, —CH2C(O)— and —C(O)CH2—; X7 is NH, CH2 or O; R1 is selected from the group consisting of cyano, halogen, C1-C3-alkyl, fluorinated C1-C3-alkyl, C3-C6-cycloalkyl, fluorinated C3-C6-cycloalkyl, C1-C3-alkoxy and fluorinated C1-C3-alkoxy; R2 is selected from the group consisting of hydrogen, cyano, halogen, C1-C3-alkyl, fluorinated C1-C3-alkyl, C3-C6-cycloalkyl, fluorinated C3-C6-cycloalkyl, C1-C3-alkoxy and fluorinated C1-C3-alkoxy; R3 and R4, independently of each other and independently of each occurrence, are selected from the group consisting of hydroxyl, C1-C4-alkyl, C1-C4-haloalkyl, C3-C6-cycloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy and NR9R10, and in case that R3 or R4 are bound to a carbon ring atom, are additionally selected from halogen; or
two non-geminal radicals R3 form together a group —(CH2)k—, where k is 1, 2, 3 or 4, where 1 or 2 hydrogen atoms in this group may be replaced by a methyl group; ortwo non-geminal radicals R4 form together a group —(CH2)k—, where k is 1, 2, 3 or 4, where 1 or 2 hydrogen atoms in this group may be replaced by a methyl group; ortwo geminal radicals R3 form together a group —(CH2)j—, where j is 2, 3, 4 or 5, where 1 or 2 hydrogen atoms in this group may be replaced by a methyl group; ortwo geminal radicals R4 form together a group —(CH2)j—, where j is 2, 3, 4 or 5, where 1 or 2 hydrogen atoms in this group may be replaced by a methyl group;with the proviso that R3 and R4 are not halogen, hydroxyl, C1-C4-alkoxy or C1-C4-haloalkoxy if they are bound to a carbon atom in α-position to a nitrogen ring atom; R5 is selected from the group consisting of hydrogen; cyano; C1-C6-alkyl; C2-C6-alkenyl; C2-C6-alkynyl; C3-C7-cycloalkyl, where the four last-mentioned radicals may be partially or fully halogenated and/or may carry one or more substituents R11; phenyl which may carry 1, 2 or 3 substituents R12; a 3-, 4-, 5-, 6- or 7-membered saturated, partially unsaturated or maximally unsaturated heteromonocyclic ring containing 1, 2 or 3 heteroatoms or heteroatom groups selected from the group consisting of O, N, S, NO, SO and SO2 as ring members; and a 5-, 6-, 7-, 8-, 9-, 10- or 11-membered saturated, partially unsaturated or maximally unsaturated heterobicyclic ring containing 1, 2 or 3 heteroatoms or heteroatom groups selected from the group consisting of O, N, S, NO, SO and SO2 as ring members, where the heteromonocyclic or heterobicyclic ring may carry 1, 2 or 3 substituents R12; —OR13; —S(O)1R13; NR14R15; and —C(═O)R16; R6 and R7, independently of each other, are selected from the group consisting of halogen, cyano, hydroxyl, C1-C3-alkyl, fluorinated C1-C3-alkyl, C1-C3-hydroxyalkyl, C1-C3-alkoxy and fluorinated C1-C3-alkoxy; each R8 is independently selected from the group consisting of halogen, cyano, hydroxyl, C1-C3-alkyl, fluorinated C1-C3-alkyl, C1-C3-hydroxyalkyl, C1-C3-alkoxy and fluorinated C1-C3-alkoxy; R9 and R10, independently of each other, are selected from the group consisting of hydrogen, C1-C4-alkyl, C1-C4-haloalkyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C4-alkyl, phenyl and benzyl; each R11 is independently selected from the group consisting of cyano; —OR13; —S(O)1R13; NR14R15; —C(═O)R16; C3-C6-cycloalkyl; C3-C6-halocycloalkyl; phenyl which may carry 1, 2 or 3 substituents R12; a 3-, 4-, 5-, 6- or 7-membered saturated, partially unsaturated or maximally unsaturated heteromonocyclic ring containing 1, 2 or 3 heteroatoms or heteroatom groups selected from the group consisting of O, N, S, NO, SO and SO2 as ring members; and a 5-, 6-, 7-, 8-, 9-, 10- or 11-membered saturated, partially unsaturated or maximally unsaturated heterobicyclic ring containing 1, 2 or 3 heteroatoms or heteroatom groups selected from the group consisting of O, N, S, NO, SO and SO2 as ring members, where the heteromonocyclic or heterobicyclic ring may carry 1, 2 or 3 substituents R12; and as a substituent on a cycloalkyl ring, R11 is additionally selected from C1-C4-alkyl or C1-C4-haloalkyl; each R12 is independently selected from the group consisting of halogen; hydroxyl; cyano; nitro; C1-C4-alkyl; C1-C4-haloalkyl; C3-C6-cycloalkyl; C3-C6-halocycloalkyl; C1-C4-alkoxy; C1-C4-haloalkoxy; C1-C4-alkylthio; C1-C4-haloalkylthio; C1-C4-alkylsulfinyl; C1-C4-haloalkylsulfinyl; C1-C4-alkylsulfonyl; C1-C4-haloalkylsulfonyl; phenyl; phenoxy; benzyloxy, where the phenyl moiety in the three last-mentioned radicals may carry 1, 2 or 3 substituents selected from the group consisting of halogen, hydroxyl, cyano, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy and C1-C4-haloalkoxy; and a 3-, 4-, 5-, 6- or 7-membered saturated, partially unsaturated or maximally unsaturated heteromonocyclic ring containing 1, 2 or 3 heteroatoms or heteroatom groups selected from the group consisting of O, N, S, NO, SO and SO2 as ring members, where the heteromonocyclic ring may carry 1, 2 or 3 substituents selected from the group consisting of halogen, hydroxyl, cyano, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy and C1-C4-haloalkoxy; each R13 is independently selected from the group consisting of hydrogen; C1-C4-alkyl; C1-C4-haloalkyl; C1-C4-alkyl which carries one substituent R17; C2-C4-alkenyl; C2-C4-haloalkenyl; C2-C4-alkynyl; C2-C4-haloalkynyl; C3-C6-cycloalkyl; C3-C6-halocycloalkyl; phenyl which may carry 1, 2 or 3 substituents selected from the group consisting of halogen, hydroxyl, cyano, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy and C1-C4-haloalkoxy; and a 3-, 4-, 5-, 6- or 7-membered saturated, partially unsaturated or maximally unsaturated heterocyclic ring containing 1, 2 or 3 heteroatoms or heteroatom groups selected from the group consisting of O, N, S, NO, SO and SO2 as ring members, where the heterocyclic ring may carry 1, 2 or 3 substituents selected from the group consisting of halogen, hydroxyl, cyano, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy and C1-C4-haloalkoxy; R14 and R15, independently of each other and independently of each occurrence, are selected from the group consisting of hydrogen; C1-C4-alkyl; C1-C4-haloalkyl; C3-C6-cycloalkyl; C3-C6-halocycloalkyl; phenyl which may carry 1, 2 or 3 substituents selected from the group consisting of halogen, hydroxyl, cyano, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy and C1-C4-haloalkoxy; and a 3-, 4-, 5-, 6- or 7-membered saturated, partially unsaturated or maximally unsaturated heterocyclic ring containing 1, 2 or 3 heteroatoms or heteroatom groups selected from the group consisting of O, N, S, NO, SO and SO2 as ring members, where the heterocyclic ring may carry 1, 2 or 3 substituents selected from the group consisting of halogen, hydroxyl, cyano, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy and C1-C4-haloalkoxy, C1-C4-alkylcarbonyl and C1-C4-haloalkylcarbonyl; each R16 is independently selected the group consisting of from hydrogen, C1-C4-alkyl, C1-C4-haloalkyl, C3-C6-cycloalkyl, C3-C6-halocycloalkyl, phenyl, —OR13 and NR14R15; each R17 is independently selected from the group consisting of cyano; hydroxyl; C1-C4-alkoxy; C1-C4-haloalkoxy; C1-C4-alkylthio; C1-C4-haloalkylthio; C1-C4-alkylsulfinyl; C1-C4-haloalkylsulfinyl; C1-C4-alkylsulfonyl; C1-C4-haloalkylsulfonyl; NR14R15; C1-C4-alkylcarbonyl; C1-C4-haloalkylcarbonyl; C3-C6-cycloalkyl; C3-C6-halocycloalkyl; phenyl which may carry 1, 2 or 3 substituents R12; a 3-, 4-, 5-, 6- or 7-membered saturated, partially unsaturated or maximally unsaturated heteromonocyclic ring containing 1, 2 or 3 heteroatoms or heteroatom groups selected from the group consisting of O, N, S, NO, SO and SO2 as ring members; and a 5-, 6-, 7-, 8-, 9-, 10- or 11-membered saturated, partially unsaturated or maximally unsaturated heterobicyclic ring containing 1, 2 or 3 heteroatoms or heteroatom groups selected from the group consisting of O, N, S, NO, SO and SO2 as ring members, where the heteromonocyclic or heterobicyclic ring may carry 1, 2 or 3 substituents R12; a is 0, 1 or 2; b is 0, 1 or 2; c is 0, 1 or 2; and l is 0, 1 or 2;or an N-oxide, stereoisomer, or pharmaceutically acceptable salt thereof, or wherein at least one of the atoms has been replaced by its stable, non-radioactive isotope. |
