发明名称 |
USE OF 2'-SUBSTITUTED OLIGONUCLEOTIDES TO DOWN-REGULATING GENE EXPRESSION |
摘要 |
<p>Disclosed is a method of down-regulating the expression of a gene in an animal, wherein a pharmalogical formulation comprising an oligonucleotide complementary to the gene is orally administered to an animal. The oligonucleotide administered has non-phosphodiester internucleotide linkages and includes at least one 2'-substituted ribonucleotide, the oligonucleotide inhibiting the expression of a product of the gene, thereby down-regulating the expression of the gene.</p> |
申请公布号 |
GR3032669(T3) |
申请公布日期 |
2000.06.30 |
申请号 |
GR20000400367T |
申请日期 |
2000.02.16 |
申请人 |
HYBRIDON, INC. |
发明人 |
AGRAWAL, SUDHIR;DIASIO, ROBERT, B.;ZHANG, RUIWEN |
分类号 |
C12N15/09;A61K;A61K31/70;A61K31/795;A61K48/00;A61P25/28;A61P31/12;A61P33/00;A61P33/10;A61P35/00;C07H21/00;C07H21/04;(IPC1-7):A61K31/70 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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