| 发明名称 | Cosmetic designs and products using intronic RNA | ||
| 摘要 | The present invention relates to a method and composition for generating a non-naturally occurring intron and its components capable of being processed into small hairpin RNA (shRNA) and/or microRNA (miRNA) molecules by skin cells and thus inducing specific gene silencing effects on skin pigment-related genes and/or aging-causing genes in the cells. The gene silencing effects so obtained are not only useful for lightening and whitening skin colors but also useful for suppressing unwanted aging gene activities in skins. | ||
| 申请公布号 | US9453219(B2) | 申请公布日期 | 2016.09.27 |
| 申请号 | US200712003662 | 申请日期 | 2007.12.28 |
| 申请人 | MELLO BIOTECH TAIWAN CO., LTD. | 发明人 | Lin Shi-Lung;Wu David TS |
| 分类号 | C12N15/113;C12N15/11 | 主分类号 | C12N15/113 |
| 代理机构 | Birch, Stewart, Kolasch & Birch, LLP | 代理人 | Birch, Stewart, Kolasch & Birch, LLP |
| 主权项 | 1. An isolated nucleic acid composition for inducing microRNA mir-434-associated gene silencing effects against tyrosinase, comprising: a SpRNAi-RGFP expression vector capable of expressing an intronic RNA molecule having a sequence which contains the sequence of SEQ.ID.NO:8, wherein the intronic RNA molecule having the sequence of SEQ.ID.NO.8 targets tyrosinase gene. | ||
| 地址 | Taipei TW | ||