发明名称 |
DESIGNED ANKYRIN REPEAT DOMAINS WITH BINDING SPECIFICITY FOR SERUM ALBUMIN |
摘要 |
New designed ankyrin repeat domains with binding specificity for serum albumin, recombinant binding proteins comprising at least two designed ankyrin repeat domains with binding specificity for serum albumin, as well as recombinant binding proteins comprising at least one designed ankyrin repeat domain with binding specificity for hepatocyte growth factor (HGF), at least one designed ankyrin repeat domain with binding specificity for vascular endothelial growth factor (VEGF-A), and at least two designed ankyrin repeat domain with binding specificity for serum albumin are described, as well as nucleic acids encoding such designed ankyrin repeat domains and recombinant binding proteins, pharmaceutical compositions comprising such designed ankyrin repeat domains, recombinant binding proteins or nucleic acids and the use of such designed ankyrin repeat domains, recombinant binding proteins, nucleic acids or pharmaceutical compositions in the treatment of diseases. |
申请公布号 |
WO2016156596(A1) |
申请公布日期 |
2016.10.06 |
申请号 |
WO2016EP57272 |
申请日期 |
2016.04.01 |
申请人 |
MOLECULAR PARTNERS AG |
发明人 |
BAKKER, Talitha;STUMPP, Michael T.;BINZ, Hans Kaspar;PHILLIPS, Douglas;DOLADO, Ignacio;FORRER, Patrik;MERZ, Frieder W.;SONDEREGGER, Ivo;STEINER, Daniel;GULOTTI-GEORGIEVA, Maya;ABRAM SALIBA, Johan |
分类号 |
C07K14/475;A61K38/00;C07K14/47;C07K14/765;C07K16/22;C07K16/28 |
主分类号 |
C07K14/475 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|