发明名称 |
AN IMPROVED PROCESS FOR THE PREPARATION OF BISOPROLOL AND ITS INTERMEDIATE |
摘要 |
The present invention provides an improved process for the preparation of 4-((2-isopropoxy ethoxy) methyl) phenol compound (I), used as an intermediate in many organic synthesis; particularly a key intermediate for the synthesis of l-[4[2(l-methylethoxy) ethoxy methyl] phenoxy]-3-(l-methylethylamino)-propan-2-ol; commonly known as Bisoprolol or its pharmaceutically acceptable salts. The process comprises reacting the 4-hydroxybenzyl alcohol (II) with the 2-isopropoxyethanol (III) in the presence of activated silica and optionally, in the presence of solvent. |
申请公布号 |
WO2016135616(A1) |
申请公布日期 |
2016.09.01 |
申请号 |
WO2016IB50949 |
申请日期 |
2016.02.23 |
申请人 |
PIRAMAL ENTERPRISES LIMITED |
发明人 |
MORTHALA, Raghavendar Rao;GHARPURE, Milind;JAGTAP, Ashutosh;MHASKAR, Mahesh;KRISHNMURTHY, Dhileepkumar |
分类号 |
C07C41/09;C07C41/46;C07C43/164 |
主分类号 |
C07C41/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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