发明名称 |
SYSTEMS FOR DETECTING, MONITORING OR TREATING DISEASES OR CONDITIONS USING ENGINEERED CELLS AND METHODS FOR MAKING AND USING THEM |
摘要 |
Provided are methods for detecting and treating disease states, including cancer, diabetes, fibrosis, and autoimmune diseases, by detecting increased mechanical modulus, or stiffness, or targeting tissues having increased mechanical modulus, or stiffness. Practicing these methods provides specific and localized detection assays and therapies for these disease states. Provided are mechano-responsive cell systems that can selectively detect and treat cancer metastases by targeting the unique biophysical and mechanical properties in the tumor microenvironment. Provided are methods for making mechano-sensitive CAR T cells by using mechano-responsive promoter logic. Provided are blood tests using engineered stem cells that express reporters after the cells home to a specific niche and secrete the reporter into the blood, which can be then be detected with a blood test. In alternative embodiments, provided are ultrasensitive detection platforms, able to detect target molecules or cells in blood with single-molecule or single-cell sensitivity. |
申请公布号 |
WO2016172359(A3) |
申请公布日期 |
2016.12.01 |
申请号 |
WO2016US28675 |
申请日期 |
2016.04.21 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
ZHAO, Weian;ECKERT, Mark A.;LIU, Linan;LIAO, Wenbin;KANG, Dongku;PONE, Egest J.;ZHANG, Shirley X.;LU, Mengrou;ZIMAK, Jan |
分类号 |
A61K39/395;A61P31/00;C07K16/00;C07K16/18;C12N15/63 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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