发明名称 |
SYNTHESIS OF ENANTIOMERICALLY PURE AMINO-SUBSTITUTED FUSED BICYCLIC RINGS |
摘要 |
This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems. |
申请公布号 |
PL372705(A1) |
申请公布日期 |
2005.07.25 |
申请号 |
PL20020372705 |
申请日期 |
2002.09.12 |
申请人 |
ANORMED INC. |
发明人 |
MCEACHERN ERNEST J.;BRIDGER GARY J.;SKUPINSKA KRYSTYNA A.;SKERLJ RENATO T. |
分类号 |
C12P17/12;C07D215/06;C07D215/20;C07D215/38;C07D215/40;C07D215/42;C07D215/44;C07D215/48;C07D217/02;C07D221/04;C07D241/40;C07D241/42;C07D307/79;C07D491/04;C07D491/052 |
主分类号 |
C12P17/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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