| 发明名称 |
PHARMACOKINETIC AND PHARMACODYNAMIC MODELING OF ERYTHROPOIETIN ADMINISTRATION |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a means for determining a good administration route for administering EPO, and effective doses and dosage regimens for administering the EPO. <P>SOLUTION: This method for obtaining optimized EPO dosage regimens for a desired pharmacodynamic response in patients comprises (a) a process for choosing one or more EPO dosage regimens, (b) a process for using a pharmacokinetic/pharmacodynamic model to determine the pharmacodynamic profile of one or more EPO dosage regimens, and (c) a process for selecting one of the EPO dosage regimens for administration to achieve the desired pharmacodynamic response based on the EPO profile. <P>COPYRIGHT: (C)2005,JPO&NCIPI |
| 申请公布号 |
JP2005247858(A) |
申请公布日期 |
2005.09.15 |
| 申请号 |
JP20050093310 |
申请日期 |
2005.03.28 |
| 申请人 |
ORTHO-MCNEIL PHARMACEUTICALS INC |
发明人 |
CHEUNG WING;DAVID GIBSON;VERCAMMEN ELS;COTE CHRISTINE |
| 分类号 |
A61K38/00;A61K31/282;A61K31/7072;A61K33/24;A61K38/12;A61K38/18;A61K38/22;A61M37/00;A61P7/00;A61P7/06;A61P7/08;A61P13/12;A61P19/02;A61P29/00;A61P31/18;A61P35/00;A61P43/00;G06F19/00;G06Q10/00 |
主分类号 |
A61K38/00 |
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