| 发明名称 |
PDK1 BINDING MOLECULES AND USES THEREOF |
| 摘要 |
The present invention is based, at least in part, on the discovery that PDK1 is associated with the outer plasma membrane of the cell. Accordingly, the present invention encompasses 3-phosphoinositide-dependent protein kinase-1 (PDK1) binding molecules, such as an antibody. The binding molecules of the invention are useful for detecting PDK1 and for inhibiting PDK1 activity, e.g., in a human subject having a disorder in which PDK1 activity is detrimental, such as a cancer. |
| 申请公布号 |
US2016319035(A1) |
申请公布日期 |
2016.11.03 |
| 申请号 |
US201514961492 |
申请日期 |
2015.12.07 |
| 申请人 |
Dessain Scott Kendall;Heimbach Baron Christopher |
发明人 |
Dessain Scott Kendall;Heimbach Baron Christopher |
| 分类号 |
C07K16/40;G01N33/574;C07K14/705;C07K16/30;A61K39/395;C07K14/725 |
主分类号 |
C07K16/40 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A binding molecule which binds to extracellular 3-phosphoinositide-dependent protein kinase-1 (PDK1). |
| 地址 |
Wynnewood PA US |
