Process for making beta -O-cellobiosyl steroid derivatives and trimethyl silyl steroid intermediates used therein

摘要

PCT No. PCT/US93/01709 Sec. 371 Date Dec. 20, 1994 Sec. 102(e) Date Dec. 20, 1994 PCT Filed Mar. 2, 1993 PCT Pub. No. WO94/00478 PCT Pub. Date Jan. 6, 1994A process for the synthesis of peracyl-1-O-steroidal- beta -cellobiosides that provides excellent beta -anomeric selectivity without the use of a metal salt promoter. The process comprises reacting heptaacyl- beta -D-cellobiosyl-1-fluoride and a trisubstituted silyl-3-O-steroid, wherein the steroid is tigogenin, hecogenin, 11-ketotigogenin or diosgenin in the absence of a metal salt under suitable conditions.