Indole carboxamide derivatives and uses thereof

摘要

A compound of Formula (I) is provided that has been shown to be useful for treating a disease, disorder or syndrome that is mediated by the transportation of essential molecules in the mmpL3 pathway:;
wherein R1, R2, R3, R4, R5 and R6 are as defined herein.

主权项

1. A compound of Formula (I)wherein:
R1 is H; R2 is H, methyl, trifluoromethyl, chloro, bromo, fluoro, or cyano; R3 is H; R4 is H, methyl, trifluoromethyl, chloro, bromo, fluoro, cyano, or (phenyl)NH—; R5 is H or chloro;provided that R2, R3, R4 and R5 are not all hydrogen;
R6 is (C5-C7)cycloalkyl or —CH2-(cyclohexyl), where said (C5-C7)cycloalkyl is optionally substituted with one to two substituents each independently selected from halo, methyl, isopropyl, fluoro-substituted methyl, and ethynyl, provided that R6 is not an unsubstituted cyclohexyl, when R2 and R4 are both methyl; or a pharmaceutically acceptable salt thereof.