| 发明名称 |
RNAi-mediated inhibition of connexin 43 for treatment of IOP-related conditions |
| 摘要 |
RNA interference is provided for inhibition of connexin 43 (Cx43) in intraocular pressure-related conditions, including ocular hypertension and glaucoma such as normal tension glaucoma and open angle glaucoma. |
| 申请公布号 |
US9476047(B2) |
申请公布日期 |
2016.10.25 |
| 申请号 |
US201514859484 |
申请日期 |
2015.09.21 |
| 申请人 |
Arrowhead Pharmaceuticals, Inc. |
发明人 |
Chatterton Jon E.;Clark Abbot F.;Wax Martin B. |
| 分类号 |
C12N15/11;A61K48/00;C12N15/113;A61K31/713 |
主分类号 |
C12N15/11 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A composition comprising an interfering RNA and a pharmaceutically acceptable carrier wherein said interfering RNA comprises a double stranded RNA having a first strand 19-49 nucleotides in length and a second strand 19-49 nucleotides in length wherein the first strand comprises SEQ ID NO: 79 or SEQ ID NO: 80. |
| 地址 |
Pasadena CA US |
