Process for the preparation of 4-alkoxy-3-hydroxypicolinic acids

摘要

4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and bromination-rearrangement. 4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 4,6-dibromo-3-hydroxypicolinonitrile in a series of chemical steps selected from bromo substitution, nitrile hydrolysis and halogen reduction.

主权项

1. A compound selected from the group consisting of: wherein R1 is a C1-C3 alkyl; wherein R1 is a C1-C3 alkyl; and wherein R1 is a C2-C3 alkyl.