| 摘要 |
An N-aryl piperidine substituted biphenylcarboxaminde compound is described having apolipoprotein B inhibiting activity and concomitant lipid lowering activity. The compound of formula (I) is described wherein R1 is hydrogen, C1-4alkyl, halo, or polyhaloC1-4alkyl; R2 is hydrogen, C1-4alkyl, halo, or polyhaloC1-4alkyl; R3 is hydrogen or C1-4alkyl; R4 is hydrogen, C1-4alkyl, or halo; n is an integer zero or 1; X1 and X2 are either both carbon, or when one of X1 or X2 is nitrogen, then the other X1 or X2 is carbon; X3 is carbon, or nitrogen provided that only one of X1 or X2 is nitrogen; Y is O or NR6 wherein R6 is hydrogen or C1- 4alkyl; and R5 is hydrogen, C1-6alkyl optionally substituted, C1-6alkenyl optionally substituted; C3-6 alkynyl optionally substituted, aryl or heteroaryl. The use of the compounds in a medicament for the treatment of hyperlipidemia, obesity and type II diabetes is disclosed, as well as the methods of preparing such compounds.
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