| 发明名称 |
MIXED ORL1/MU-AGONISTS FOR THE TREATMENT OF PAIN |
| 摘要 |
The invention relates to the use of compounds having an affinity for the µ opioid receptor of at least 100 nM (Ki human value) and an affinity for the ORL-1 receptor for producing a medicament for treating pain, the ratio between the ORL1/µ affinities defined as 1/[Ki(ORL1)/Ki(µ)] being between 0.1 and 30. |
| 申请公布号 |
CA2664702(C) |
申请公布日期 |
2016.08.09 |
| 申请号 |
CA20072664702 |
申请日期 |
2007.09.26 |
| 申请人 |
GRUENENTHAL GMBH |
发明人 |
LINZ, KLAUS;KOEGEL, BABETTE-YVONNE;SCHROEDER, WOLFGANG;CHRISTOPH, THOMAS;DE VRY, JEAN;FRIDERICHS, ELMAR |
| 分类号 |
A61K31/407;A61K31/438;A61P25/04 |
主分类号 |
A61K31/407 |
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