Sorbent comprising on its surface an aliphatic unit for the purification of organic molecules

摘要

The present invention relates to a sorbent comprising a solid support material, the surface of which comprises a residue of a general formula (I), wherein the residue is attached via a covalent single bond to a functional group on the surface of either the bulk solid support material itself or of a polymer film on the surface of the solid support material. Furthermore, the present invention relates to the use of the sorbent according to the invention for the purification of organic molecules, in particular pharmaceutically active compounds, preferably in chromatographic applications.

主权项

1. A sorbent for the purification of organic molecules exhibiting both a hydrophilic and a hydrophobic moiety, the sorbent comprising a solid support material, wherein the surface of the solid support material comprises a residue of the following general formula (I):
------L-X   formula (I), wherein the residue is attached via a covalent single bond represented by the dotted line in formula (I) to a functional group on the surface of a polymer film on the surface of the solid support material, wherein the polymer of the polymer film comprises individual chains which are covalently crosslinked with each other, and wherein the individual chains are not covalently bound to the surface of the solid support material, wherein the polymer is a polyvinylamine, and wherein:
(a) L represents a covalent single bond or is a bivalent unit selected from the group consisting of —C(O)—, —S(O)2—, and —CH2CH(OH)—;(b) X represents a linear C6-C15 alkyl.