发明名称 |
Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2 |
摘要 |
Cyclooxygenase (COX2) and inducible nitric oxide synthase (iNOS) are two major inflammatory mediators. Inducible NOS specifically binds to COX2 and S-nitrosylates it, enhancing COX2 catalytic activity. Selectively disrupting iNOS-COX2 binding prevents NO-mediated activation of COX2. The synergistic molecular interaction between two inflammatory systems permits assays for developing anti-inflammatory drugs.
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申请公布号 |
US7358237(B2) |
申请公布日期 |
2008.04.15 |
申请号 |
US20060413201 |
申请日期 |
2006.04.28 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
SNYDER SOLOMON H.;KIM SANGWON |
分类号 |
A61K38/10;A61K38/16 |
主分类号 |
A61K38/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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