| 发明名称 | Parathyroid hormone analogs and uses thereof | ||
| 摘要 | Disclosed are two PTH analog ligands, SP-PTH-AAK and Aib-SP-PTH-AAK, that have long-acting activity at the PTH receptor, as demonstrated both in vitro and in vivo. These polypeptides are thus particularly useful in the treatment of diseases, such as hypoparathyroidism, in which long-acting activity is desired. The method of making the analog polypeptides is also disclosed. | ||
| 申请公布号 | US9492508(B2) | 申请公布日期 | 2016.11.15 |
| 申请号 | US201113697249 | 申请日期 | 2011.05.12 |
| 申请人 | The General Hospital Corporation;Chugai Seiyaku Kabushiki Kaisha | 发明人 | Gardella Thomas J.;Potts, Jr. John T.;Jueppner Harald;Okazaki Makoto |
| 分类号 | A61K38/29;C07K14/635 | 主分类号 | A61K38/29 |
| 代理机构 | Clark & Elbing LLP | 代理人 | Clark & Elbing LLP |
| 主权项 | 1. A polypeptide comprising formula (I): (I)SEQ ID NO: 1X01-Val-X03-Glu-Ile-Gln-Leu-X08-His-X10-X11-X12-X13-X14-X15-X16-X17-X18-Arg-Arg-Arg-X22-Phe-Leu-X25-X26-Leu-Ile-Ala-Glu-Ile-His-Thr-Ala-Glu-Ile X01 is Ser or Ala; X03 is Ser, Ala, or Aib; X08 is Met, Leu, or Nle; X10 is Asn or Gln; X11 is Leu, Arg, or Har; X12 is Gly or Ala; X13 is Lys; X14 is His or Trp; X15 is Ile; X16 is Gln; X17 is Asp; X18 is Ala; X22 is Ala; X25 is His; and X26 is Lys; or a pharmaceutically acceptable salt thereof. | ||
| 地址 | Boston MA US | ||