3-dimensional silk hydroxyapatite compositions

摘要

Described herein are methods and compositions comprising a mixture of silk polymer and hydroxyapatite. The methods described herein can be used to prepare a mixture of silk polymer and hydroxyapatite and further provide mixtures that can be molded into a desired shape. Also encompassed herein are compositions comprising a mixture of silk polymer and hydroxyapatite having a desired shape, which can further be implanted, for example, to facilitate bone healing or tooth structure or support. Such compositions can also include agents, such as therapeutic agents, or cells.

主权项

1. An article of manufacture comprising:
(a) a mixture of silk fibroin polymer substantially free of sericin and hydroxyapatite particles, wherein (b) the mixture further comprises non-dissolved raw silk fibers that structurally reinforce the silk fibroin polymer,wherein said silk fibroin polymer is formed into an insoluble state about said hydroxyapatite particles in the presence of said hydroxyapatite particles.